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J.Pharma · Cognitive Health · Research Peptide

Semax

Synthetic ACTH/MSH analogue with nootropic and neuroprotective properties. BDNF upregulation and cognitive function research — available in 10mg.

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Cognitive Health · Research Compound

About Semax

Semax is a heptapeptide (7 amino acids) derived from the ACTH (adrenocorticotropic hormone) fragment 4-7, with three additional Pro-Gly-Pro amino acids attached. It was developed in Russia and has been the subject of research in neuroprotection and cognitive function. Unlike full-length ACTH, Semax lacks hormonal activity at adrenal receptors, making it selectively active at neurological targets.

Semax research has demonstrated significant upregulation of BDNF (brain-derived neurotrophic factor), a protein critical for neuronal survival, growth, and synaptic plasticity. It also influences NGF (nerve growth factor) expression and has been studied for effects on serotonin, dopamine, and acetylcholine systems. In animal models it has shown neuroprotective effects in ischemia models and cognitive enhancement in learning and memory tasks. Semax can be administered intranasally, making it a subject of research interest for transmucosal peptide delivery.

Purity
≥99%
HPLC-UV verified
Identity
LC-MS Confirmed
Mass spectrometry
Form
Lyophilized Powder
Requires reconstitution
Storage
Lyophilized: Refrigerate at 2–8°C. More temperature-sensitive than many peptides.
After reconstitution: 2–8°C
Available Sizes
10mg
Lyophilized powder · 99%+ purity
$60
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🧪 Reconstitution
Reconstitute with 2 mL Bacteriostatic Water (5 mg/mL). Solution is clear and colorless. For intranasal research protocols, a nasal spray atomizer can be used for administration — some researchers use a more dilute concentration for this application. Inject BAC Water slowly down the vial wall. Swirl gently. Refrigerate at 2–8°C after reconstitution. Stable 28–42 days. Visit our full Reconstitution Guide and Dosing Calculator for detailed instructions.
Research Context

Research Applications

Semax is used in research investigating BDNF upregulation, neuroprotection, neurogenesis, cognitive function modulation, memory and learning, serotonin and dopamine system interactions, and intranasal peptide delivery. It is of interest in research on neurotrophic factor modulation and peptide-based approaches to neuroprotection.

For research use only. All products sold by J.Pharma are intended strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for any therapeutic purpose.
FAQ

Common Questions

What is Semax?
Semax is a synthetic heptapeptide derived from a fragment of ACTH with three additional amino acids (Pro-Gly-Pro). It was developed in Russia and has been studied for nootropic and neuroprotective effects, particularly BDNF upregulation and cognitive enhancement in animal models.
Can Semax be administered intranasally?
Yes — intranasal administration is a common research protocol for Semax, taking advantage of the nasal mucosa as a transmucosal delivery route. A nasal spray atomizer is used for this application. Some researchers use a more dilute concentration than the standard injectable protocol.
How do I reconstitute Semax?
Use 2 mL Bacteriostatic Water for the 10mg vial (5 mg/mL). Solution is clear and colorless. Refrigerate after reconstitution. Stable 28–42 days at 2–8°C.
What is BDNF and why is it relevant to Semax research?
BDNF (brain-derived neurotrophic factor) is a protein that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. It plays a central role in learning, memory, and neuroprotection. Semax research has demonstrated significant BDNF upregulation, which is the primary basis for its nootropic research applications.
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Regulatory Notice

None of the statements on this website have been reviewed or approved by the U.S. Food and Drug Administration. J.Pharma products are not intended to diagnose, treat, cure, or prevent any disease or medical condition. All products are sold strictly for in vitro laboratory research purposes. They are not for human or animal use of any kind. DiPerna Services, LLC d/b/a J.Pharma is not a compounding pharmacy or outsourcing facility as defined under Sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act.